E8. To be completed after lesson 22

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Exercise 8.1

Why can’t we use scipy.optimize.least_squares() on the Singer data for mRNA counts from smFISH experiments?

Exercise 8.2

In your mind, is there a fundamental difference between maximum likelihood estimation for variate-covariate models and the other parametric models we have encountered before?

Exercise 8.3

Write down any questions or points of confusion that you have.